| Indications :
Hypercalcemia of Malignancy (Moderate to Severe) Paget's disease Osteolytic Bone Metastases of Breast Cancer
Osteolytic Lesions of Multiple Myeloma
Dosage :
Moderate Hypercalcemia (serum calcium 12-13.5 mg/dL): 60 to 90 mg given as a single-dose,
intravenous infusion over 2 to 24 hours.
Severe Hypercalcemia (serum calcium >13.5 mg/dL): 90 mg given as a single-dose,
Intravenous infusion over 2 to 24 hours.
Paget's disease (Moderate to Severe): 30 mg daily, administered as a 4-hour infusion on 3
Consecutive days for a total dose of 90 mg.
Osteolytic Lesions of Multiple Myeloma: 90 mg administered as a 4-hour infusion given on a
Monthly basis.
Osteolytic Bone Metastases of Breast Cancer: 90 mg administered over a 2-hour infusion given
Every 3-4 weeks.
Dosage Adjustment:
Renal Impairment: Required.
Hepatic Impairment: Not well studied, administer with caution.
Packing : Single dose Vial of 30 mg / 60 mg / 90 mg / Vial
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